Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation
نویسندگان
چکیده
منابع مشابه
Tunicamycin inhibits mouse tooth morphogenesis and odontoblast differentiation in vitro.
Tunicamycin (TM), an antibiotic that selectively inhibits dolichol-mediated protein glycosylation, inhibited morphogenesis and differentiation of odontoblasts in the molar tooth germ in vitro. These effects of TM are reversible and dose-dependent, and in advanced teeth the effect of TM was not complete unless the basement membrane was removed prior to culture. TM did not prevent secretion of pr...
متن کاملNuclear Factor I-C Is Essential for Odontogenic Cell Proliferation and Odontoblast Differentiation during Tooth
From the Department of Oral Histology-Developmental Biology, Dental Research Institute, Conservative Dentistry, **Oral & Maxillofacial Surgery, and Tooth Bioengineering National Research Lab, School of Dentistry, Seoul National University, Seoul 110-749, Korea and the Department of Biochemistry and the Program in Neuroscience, School of Medicine and Biomedical Science, and the Department of Ora...
متن کاملTWIST1 promotes the odontoblast-like differentiation of dental stem cells.
Stem cells derived from the dental pulp of extracted human third molars (DPSCs) have the potential to differentiate into odontoblasts, osteoblasts, adipocytes, and neural cells when provided with the appropriate conditions. To advance the use of DPSCs for dentin regeneration, it is important to replicate the permissive signals that drive terminal events in odontoblast differentiation during too...
متن کاملWnt10a regulates dentin sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis.
We have explored the role of Wnt signaling in dentinogenesis of mouse molar teeth. We found that Wnt10a was specifically associated with the differentiation of odontoblasts and that it showed striking colocalization with dentin sialophosphoprotein (Dspp) expression in secretory odontoblasts. Dspp is a tooth specific non-collagenous matrix protein and regulates dentin mineralization. Transient o...
متن کاملNuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development.
Our previous studies have demonstrated that nuclear factor I-C (NFI-C) null mice developed short molar roots that contain aberrant odontoblasts and abnormal dentin formation. Based on these findings, we performed studies to elucidate the function of NFI-C in odontoblasts. Initial studies demonstrated that aberrant odontoblasts become dissociated and trapped in an osteodentin-like mineralized ti...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.680546